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Tramadol for osteoarthritis

Cepeda MS, Camargo F, Zea C, Valencia L

Summary

This summary of a Cochrane review presents what we know from research about the effect of tramadol for osteoarthritis. The review shows that:

There is gold level BUY TRAMADOL evidence that to treat osteoarthritis, tramadol taken for up to three months may decrease pain, may improve stiffness and function and overall-well being. Tramadol may cause side effects such as nausea, vomiting, dizziness, constipation, tiredness, and headache.

The benefits of tramadol are small and the side effects may cause people BUY TRAMADOL to stop taking it which may limit how useful tramadol is to treat osteoarthritis.

What is osteoarthritis and what drugs are  used to treat it?
Osteoarthritis (OA) is the most common form of arthritis that can affect the hands, BUY TRAMADOL hips, shoulders and knees. In OA, the cartilage that protects the ends of the bones breaks down and causes pain and swelling. There are two main types of drug treatments in OA. Pain relievers (such as  acetaminophen/paracetamol and opiods) are used to relieve pain but do not affect BUY TRAMADOL swelling. Non-steroidal anti-inflammatory drugs (NSAIDs, such as ibuprofen and cox IIs) are used to decrease pain and swelling. Tramadol is a type of opioid being used more for OA. It does not cause bleeding in the stomach and intestines or kidney problems that may occur with other pain relievers. It also does not affect the cartilage at the end of the BUY TRAMADOL bones. But tramadol does not decrease swelling and may not work well after long use. It is therefore important to know the benefits and harms of tramadol.

 What are the results of this review?
People in the studies took about 200 mg of tramadol per day or a placebo (fake tablets or powder) or an NSAID or a different pain reliever. People took the drugs for up BUY TRAMADOL to one week to three months.

Benefits of tramadol
In people with osteoarthritis:

• tramadol may decrease pain more than a placebo

-pain  may decrease by 8.5 more points on a scale of 0 to 100 with tramadol

• tramadol may improve overall well-being more than BUY TRAMADOL placebo

- 50 out of 100 people may improve when taking a placebo
- 69 out of 100 people may improve when taking tramadol

•  tramadol may slightly decrease stiffness and slightly improve function more than placebo

- function may improve by 0. BUY TRAMADOL 32 more points on a scale of 0 to10 with tramadol

It is not known whether tramadol improves symptoms of osteoarthritis more than other drugs. It is also not known whether tramadol still works well after long useThis is because the follow -up of the studies was short.

Harms of tramadol
In people with osteoarthritis:

• tramadol may cause minor side effects in more people BUY TRAMADOL than placebo, such as nausea, vomiting, dizziness, constipation, tiredness, and headache

- 18 out of 100 people may have minor side effects when taking a placebo
- 39 out of 100 people may have minor side effects when taking tramadol

• tramadol may  cause major side BUY TRAMADOL effects that would make people stop taking it

- 8 out of 100 people had major side effects when taking a placebo
- 21 out of 100 people had major side effects when taking tramadol

It is not known whether tramadol causes more side effects than other drugs for osteoarthritis.

8:08 AM - Tuesday, March 11, 2008